From 1:00pm

Registration

From 7:30am

Registration/ Poster set up (Frazer Room)

8:55 am

WELCOME

Carol black + robert lafyatis

Session 1

Scleroderma Pathogenesis– State of the Art

Chairs – Tom Medsger and Robert Simms

09:00-09:05

Introduction

TOM MEDSGER (usa)

09:05-09:30

Clinical phenotypes and disease assessment

JIM SEIBOLD (usa)

09:30-09:55

Vascular Pathogenesis

oliver Distler (Switzerland)

09:55-10:20

Immune Pathogenesis

ALAN TYNDALL (Switzerland)

10:20-10:50

COFFEE

10:50-11:15

Pulmonary Fibrosis

RICK SILVER (USA)

11:15-11:40

Genetics of Scleroderma

FRANK ARNETT (USA)

11:40-12:10

Discussion – led by Robert Simms

12:15-1:30

LUNCH

Session 2

Genes and Genetics

Chairs – Ken Welsh and Bashar Kahaleh

1:30-1:35

Introduction

KEN WELSH (uk)

1:35-2:10

Key Note

Epigenetics and autoimmunity

BRUCE RICHARDSON (USA)

2:10-2:35

Epigenetics in scleroderma

Bashar Kahaleh (USA)

2:35-3:00

Gene expression profiling

rachel chambers (uk)

3:00-3:30

Discussion led by Bashar Kahaleh

3:30-3:55

TEA

3:55-4:35

SNPs and other polymorphisms

JOSEPHINE HOH (USA)

4:35-4:55

Discussion led by Ken Welsh

5:00-5:45

Young Investigator Awards

5:45

END OF SESSION

7:00-9:00

WELCOME RECEPTION/ POSTER VIEWING

Session 3

Cell signalling

Chairs – John Varga and Humphrey Gardner

09:00-09:05

Introduction

JOHN VARGA (usa)

09:05-09:40

Key Note

Regulation of TGFb and the epithelium-mesenchyme interface

DEAN SHEPPARD  (USA)

09:40-10:10

MAP kinase signalling pathways – life or death decisions by the cell

Simon Cook  (UK)

10:10-10:40

COFFEE

10:40-11:10

JNK kinase signalling and regulation of cell fate

Roger Davis  (USA)

11:10-12:10

Discussion led by Humphrey Gardner

12:15-1:15

LUNCH

Session 4

Functional Proteomics and the ECM

Chairs –Justin Hsuan and Chris Denton

1:15-1:20

Introduction

chris denton (uk)

1:20-1:55

Key Note

Mapping post-translational protein modification with mass spectrometry

Natalie Ahn (USA)

1:55-2:20

Fibrillins: regulators of morphogenesis and tissue remodeling

FRANCESCO RAMIREZ (USA)

2:20-2:45

Syndecan Proteoglycans in wound healing and repair

JOHN COUCHMAN (Copenhagen)

2:45-3:00

TEA

3:00-3:25

Integrins and the Extracellular Matrix

THOMAS KRIEG (Germany)

3:25-3:55

Discussion led by Justin Hsuan

3:55-5:00

FREE TIME/ VIEWING OF POSTERS

Session 5 (PARALLEL SESSIONS A AND B)

Session 5A

Animal Models

Chairs – James Leiper and David Abraham

5:00-5:05

Introduction

DAVID ABRAHAM (UK)

5:05-5:40

Key Note

Mouse Molecular Genetics

BENOIT DE CROMBRUGGHE (USA)

5:40-6:05

Cavelion knockout: A novel animal model of Systemic Sclerosis

SERGIO JIMENEZ (USA)

6:05-6:30

The Tsk2 mouse – a model for dermal fibrosis – an update

STEPHEN CLARK (USA)

6:30-7:00

Discussion led by David Abraham

7:00

End of Session

FREE EVENING

Session 5B

Scientific basis for common clinical challenges in scleroderma

Chairs – Phil Clements and Fred Wigley

5:00-5:10

Introduction

FRED wIGLEY  (USA)

5:10-5:30

When is lung fibrosis trivial?

ATHOL WELLS (uk)

5:30-5:50

Towards a combined response index in scleroderma

DINESH KHANNA (usa)

5:50-6:10

Capillaroscopy – predictor or marker of damage?

ARIANE HeRrick (uk)

6:10-6:40

Panel discussion

speakers and chaIrs

6:40

END OF SESSION

FREE EVENING

Session 6

Vascular Biology

Chairs  – Peter Weissberg and Gerry Coghlan

08:45-08:50

Introduction

Peter WeisSberg (uk)

08:50-09:25

Key Note

Research Directions for the 21st Century

Jeremy Pearson (UK)

09:25-09:50

Pulmonary Vascular Function

Robert Naeije (Belgium)

09:50-10:15

Circulating Endothelial Cell Progenitors in scleroderma

MASATAKA KUwana (Japan)

10:15-10:45

COFFEE

10:45-11:15

Discussion led by Peter Weissberg

Session 7

Pulmonary Arterial Hypertension

Chairs – Hap Farber and Martine Clozel

11:15-11:40

Lessons from the past – Epoprostenol to ERA

David Badesch (usa)

11:40-12:05

Integration of ERA into Combination Therapy

GERRY COGHLAN (UK)

12:15-1:15

LUNCH

1:15-1:40

Other Strategies - Horizon Scanning

Rubin Tuder (USA)

1:40-2:05

PAH Vasculopathy as a Paradigm for Scleroderma

Hap Farber (USA)

2:05-2:40

KEYNOTE

Investigations into the pathogenesis of stiff skin syndrome

HARRY DIETZ (USA)

2:40-2:55

BREAK

Session 8

Immunology and Autoimmunity

Chair – Barbara White and Kazuhiko Takehara

2:55-3:00

Introduction

Barbara White (USA)

3:00-3:35

Key Note

Regulatory T-cells in autoimmunity

ARNE AKBAR (UK)

3:35-4:00

TLRs – universal sensors of pathogens and tissue damage

felix randow (UK)

4:00-4:25

CD4+ T-cell subpopulation TH17 in the pathogenesis of systemic scleroderma

BENT DEULERAN (Denmark)

4:25-4:55

Discussion led by Barbara White

4:55-5:15

TEA

Session 9

B-cells and autoimmune

Chairs – Arnold Postlethwaite and Neil McHugh

5:15-5:20

Introduction